Jun-Lin Guan Selected Research

Lymphangiosarcoma

1/2020	Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation.
12/2015	Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling.

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Jun-Lin Guan Research Topics

Disease

40	Neoplasms (Cancer) 01/2022 - 01/2004
22	Breast Neoplasms (Breast Cancer) 01/2022 - 08/2005
8	Carcinogenesis 01/2021 - 01/2009
8	Neoplasm Metastasis (Metastasis) 01/2020 - 02/2010
4	Starvation 01/2022 - 04/2009
4	Tuberous Sclerosis (Bourneville's Disease) 11/2019 - 10/2006
3	Triple Negative Breast Neoplasms 01/2018 - 02/2015
3	Infections 10/2017 - 10/2013
2	Ovarian Neoplasms (Ovarian Cancer) 01/2020 - 11/2017
2	Lymphangiosarcoma 01/2020 - 12/2015
2	Edema (Dropsy) 01/2016 - 08/2013
2	Glioblastoma (Glioblastoma Multiforme) 01/2011 - 02/2005
1	Thyroid Neoplasms (Thyroid Cancer) 01/2022
1	Glioma (Gliomas) 01/2021
1	Brain Neoplasms (Brain Tumor) 01/2021
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2020
1	Pancreatitis 01/2019
1	Hyperplasia 01/2019
1	Leukemia 05/2017
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 05/2017
1	Lung Injury 01/2016
1	Vascular Malformations 12/2015
1	Hemangiosarcoma (Angiosarcoma) 12/2015
1	Neoplastic Cell Transformation 05/2015
1	Choroidal Neovascularization 01/2015
1	Non-alcoholic Fatty Liver Disease 10/2013
1	Hemorrhage 08/2013
1	Hydrocephalus (Hydrocephaly) 03/2013
1	Hepatitis 02/2013

Drug/Important Bio-Agent (IBA)

16	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2020 - 02/2005
12	Proteins (Proteins, Gene)FDA Link 01/2020 - 08/2005
9	Phosphotransferases (Kinase)IBA 01/2022 - 02/2005
6	Phenobarbital (Luminal)FDA Link 01/2022 - 01/2009
5	Mechanistic Target of Rapamycin Complex 1IBA 01/2021 - 01/2014
4	Cyclin D1IBA 01/2019 - 02/2005
4	IntegrinsIBA 11/2015 - 06/2009
3	InterferonsIBA 01/2020 - 07/2011
3	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2020 - 06/2009
3	Amino Acids FDA Link 01/2018 - 04/2009
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2020
2	Messenger RNA (mRNA)IBA 01/2021 - 11/2017
2	Immune Checkpoint InhibitorsIBA 07/2020 - 01/2020
2	MicroRNAs (MicroRNA)IBA 01/2020 - 01/2018
2	trans-sodium crocetinate (crocetin)IBA 11/2019 - 07/2015
2	CateninsIBA 01/2018 - 08/2017
2	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 01/2014
2	AgarIBA 05/2015 - 02/2005
2	TOR Serine-Threonine KinasesIBA 01/2014 - 12/2006
2	Sirolimus (Rapamycin)FDA Link 01/2014 - 04/2009
2	Tyrosine (L-Tyrosine)FDA Link 02/2013 - 07/2009
2	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 12/2006 - 10/2006
1	BiglycanIBA 01/2022
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2022
1	LipidsIBA 01/2021
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2021
1	Deoxyglucose (2 Deoxy D glucose)IBA 01/2021
1	Estrogen ReceptorsIBA 01/2021
1	Autophagy-Related ProteinsIBA 07/2020
1	AntioxidantsIBA 01/2020
1	ElementsIBA 01/2020
1	Immunoglobulins (Immunoglobulin)IBA 01/2020
1	Complement Receptors (Complement Receptor)IBA 01/2020
1	Caspase 3 (Caspase-3)IBA 01/2020
1	MucinsIBA 01/2020
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019
1	Focal Adhesion Kinase 2IBA 01/2019
1	spautin-1IBA 01/2018
1	6-methyladenineIBA 01/2018
1	Tumor Viral Antigens (Large T Antigen)IBA 01/2018
1	Metformin (Glucophage)FDA LinkGeneric 01/2018
1	Protein Kinases (Protein Kinase)IBA 01/2018
1	ConnexinsIBA 01/2018
1	Lactic Acid (Lactate)FDA LinkGeneric 11/2017
1	NAD (NADH)IBA 11/2017
1	3' Untranslated Regions (3' UTR)IBA 11/2017
1	Chloroquine (Aralen)FDA LinkGeneric 05/2017
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2016
1	Retinaldehyde (Retinal)IBA 12/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2015
1	arginyl-glycyl-aspartic acidIBA 05/2015
1	OsteopontinIBA 05/2015
1	Caspase 8 (Caspase-8)IBA 05/2015
1	Glycoproteins (Glycoprotein)IBA 05/2015
1	Cisplatin (Platino)FDA LinkGeneric 02/2015
1	Epirubicin (Ellence)FDA LinkGeneric 02/2015
1	Paclitaxel (Taxol)FDA LinkGeneric 02/2015
1	Glutamine (L-Glutamine)FDA Link 11/2013
1	UbiquitinIBA 10/2013
1	EndotoxinsIBA 10/2013
1	AlbuminsIBA 08/2013
1	NestinIBA 03/2013
1	Matrix Metalloproteinase 14 (MT1-MMP)IBA 02/2013
1	MannosidasesIBA 02/2013

Therapy/Procedure

18	Therapeutics 01/2022 - 06/2009
3	Transplantation 06/2014 - 01/2009
1	Immunotherapy 01/2020
1	Isogeneic Transplantation 08/2017
1	Drug Therapy (Chemotherapy) 02/2015